大理石骨病、リンパ節形成不全、胸腺髄質形成不全、外胚葉形成不全、自己免疫疾患などの病態を呈する。メンデル則よりも低い比率で生まれ、生後２週令程度で死亡する。 Jun-ichiro INOUE Balb/cA (日本クレア) に10回バッククロス後、兄妹交配。 E14.1 [129P2/OlaHsd] <A HREF="https://mus.brc.riken.jp/en/mouse_of_month/sep_2012_mm" target="_blank">Mouse of the Month Sep 2012</A> Traf6 knockout mice. A 2.5 kb genomic fragment was replaced with a neomycin selection cassette. Homozygous mutant mice exhibit severe osteopetrosis and abnormal immune cell development and function, and die within around 2 weeks after birth. Homozygous mice represented only 12% of offspring. C57BL/6 background (RBRC04950), BALB/c background (RBRC05386). BALB-Traf6 KO BALB-Traf6 KO 1. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.<br>2. RECIPIENT must contact the DEPOSITOR in the case of application for any patents,any manuscripts, any public presentation,or commercial use, based on the results from the use of the BIOLOGICAL RESOURCE.<br>3. RECIPIENT must not yield the BIOLOGICAL RESOURCE to other parties or persons. Developed by Jun-ichiro Inoue, Institute of Medical Science, University of Tokyo in 1999. BALB/c background. <a href='https://brc.riken.jp/mus/pcr05386'>Genotyping protocol -PCR-</a> C.129P2(B6)-Traf6<tm1Jino> C.129P2(B6)-Traf6<tm1Jino> 東京大学医科学研究所 井上純一郎先生 (1999)E14 ES細胞。 true RBRC05386 mouse Polr2a promoter, E. coli Neomycin resistance gene, SV40 PolyA signal, mouse Traf6 genomic DNA C（3〜6か月） 条件を付加する。<br>1. 利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。<br>2. 利用者が本件リソースを用いて得られた研究成果に基づき、論文あるいは学会発表、特許等の申請、及び事業活動を行う場合は、事前に寄託者と別途協議を行う。<br>3. 本件リソースを第三者への分与することを禁止する。 東京大学医科学研究所 井上純一郎先生 (1999) E14 ES細胞。 Heterozygote x Wild-type [BALB/cAJcl] Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> C (3-6 months) 井上　純一郎