true 廣瀬　幸子 C (3-6 months) B6. FcR gamma -/-をBXSBに20代以上戻し交配して2006年までに順天堂大学で広瀬 幸子先生が作製したマウス系。 B6のES細胞を用いて作出。Ref : Park et al. j. Clin. Invest. 102 : 1229-1238. Developed by Sachiko Hirose, Department of Internal Medicine, Juntendo University School of Medicine in 2006. A neomycin selection cassette was transferred into BL/6-III ES cells to delete and replace exon 2 of Fcer1g gene. The mutant mice were backcrossed BXSB strain over 20 generations. B6. FcR gamma -/-をBXSBに20代以上戻し交配して得られたBXSBコンジェニックマウス系。交配によりY染色体はBXSBマウス由来に置換済み。 RBRC05429 IgG Fc receptor common gamma 鎖遺伝子欠損BXSBマウスで、Fc gamma RI/III/IV分子のBXSBマウスの自己免疫疾患に与える影響の解析が可能である。 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。J. Immunol., 177, 1646-1654 (2006). BXSB-Fcer1g KO BXSB. gamma-/- BXSB-Fcer1g KO BXSB. gamma-/- B6. FcR gamma -/-をBXSBに20代以上戻し交配して得られたBXSBコンジェニックマウス系。 交配によりY染色体はBXSBマウス由来に置換済み。 Sachiko HIROSE IgG Fc receptor common gamma knockout mice. BXSB background. Exon 2 of Fcer1g gene was deleted and replaced with a neomycin selection cassette. Autoimmune disease features of male were suppressed in homozygous mutant mice. Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> BXSB.B6-Fcer1g<tm1Tks>/Hros BXSB.B6-Fcer1g<tm1Tks>/Hros C（3〜6か月） In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 177, 1646-1654 (2006). herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli Neomycin resistance gene, mouse fcer1g genomic DNA Homozygote x Homozygote [or Crossing to BXSB/MpJJmsSlc (female)] Immunology and Inflammation Research <a href='https://brc.riken.jp/mus/pcr05429'>Genotyping protocol -PCR-</a> B6. FcR gamma -/-をBXSBに20代以上戻し交配して2006年までに順天堂大学で広瀬 幸子先生が作製したマウス系。B6のES細胞を用いて作出。Ref : Park et al. j. Clin. Invest. 102 : 1229-1238.