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    <dc:description xml:lang="en">Nlgn3 knockout mice. Neo-STOP-tetO (loxP-FRT-Neo-STOP-FRT-tetO-loxP) cassette was inserted just upstream of the Nlgn3 gene. Homozygous mutant mice show no obvious abnormality. tet0 mediated allele can be generated by crossing with FLP mice.</dc:description>
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    <ns1:expectedDelivery xml:lang="ja">C（3〜6か月）</ns1:expectedDelivery>
    <ns1:donorDNA>P1 Phage loxP sites, yeast FRT (flipase recombination target) sites, mouse PGK promoter, bacterial EM7 promoter (Synthetic), E. coli neo, yeast  His3 3' UTR, SV40 virus SV40 polyA signal, E. coli Tetracycline operator site, Cytomegalovirus CMV minimum promoter, mouse Nlgn3 genomic DNA</ns1:donorDNA>
    <dcterms:identifier>RBRC05451</dcterms:identifier>
    <ns1:strainDevelopment xml:lang="ja">田中先生がコロンビア大学Rene Hen Labで2007年に作成。田中先生が責任者として自由に配布して良いことになっている。2008年に生理研へ。CSL3 (129S6由来ES細胞) で作成。</ns1:strainDevelopment>
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    <skos:altLabel xml:lang="ja">Nlgn3 STOPtetO KI, B6-Nlgn3/STOPtetO KI</skos:altLabel>
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    <ns5:application>FLP/frt system</ns5:application>
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    <ns0:brs_depositor xml:lang="en">Kenji TANAKA</ns0:brs_depositor>
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    <ns5:application>Tet system</ns5:application>
    <ns1:strainDevelopment xml:lang="ja">田中先生がコロンビア大学Rene Hen Labで2007年に作成。田中先生が責任者として自由に配布して良いことになっている。2008年に生理研へ。 CSL3 (129S6由来ES細胞) で作成。</ns1:strainDevelopment>
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    <ns5:termsAndConditions xml:lang="en">In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Biol. Psychiatry, 67, 770-773 (2010).</ns5:termsAndConditions>
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    <dcterms:references rdf:resource="http://identifiers.org/pubmed/20163789"/>
    <ns5:application>Cre/loxP system</ns5:application>
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    <ns1:colonyMaintenance xml:lang="en">Homozygote x Hemizygote [or Crossing to C57BL/6JJcl]</ns1:colonyMaintenance>
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    <ns5:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。Biol. Psychiatry, 67, 770-773 (2010).</ns5:termsAndConditions>
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    <ns0:brs_depositor xml:lang="ja">田中　謙二</ns0:brs_depositor>
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    <ns5:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr05451'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns5:addinfo>
    <dc:description xml:lang="ja">Neuroligin3のノックアウト。</dc:description>
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    <ns1:colonyMaintenance xml:lang="ja">129S6に数回、B6Jに1回 (生理研への導入によるIVFでＢ６Ｊの卵を使用)、129S6に5回バッククロスしている。</ns1:colonyMaintenance>
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    <ns5:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns5:addinfo>
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    <ns1:expectedDelivery xml:lang="en">C (3-6 months)</ns1:expectedDelivery>
    <ns1:strainDevelopment xml:lang="en">Developed by Kenji Tanaka, Columbia University in 2007. CSL3 ES cells derived from 129S6/SvEvTac were used. C57BL/6 and 129 mixed background.</ns1:strainDevelopment>
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