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    xmlns:ns6="http://nbrp.jp/ontology/"
    xmlns:ns1="http://metadb.riken.jp/db/rikenbrc_mouse/"
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    xmlns:ns11="http://purl.org/net/cito/"
    xmlns:ns0="http://metadb.riken.jp/db/bioresource_schema/"
    xmlns:ns5="http://metadb.riken.jp/terms/xsearch#"
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:ns9="http://purl.obolibrary.org/obo/"
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    </ns0:brs_hasGenomicFeature>
    <rdfs:subClassOf rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/Strain"/>
    <dc:description xml:lang="en">Nlgn3-tetO knock-in mice. tetO was inserted just upstream of the Nlgn3 gene. Expression pattern of the mutant allele is the same as that seen in wild-type mice. By the combination with tTA and tTS, tTA-mediated overexpression and tTS-mediated knockout can be generated respectively in the absence of doxycycline and restore when restore when the antibiotic is administered to the animal.</dc:description>
    <ns1:references rdf:parseType="Resource">
    </ns1:references>
    <ns11:citesAsAuthority rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/20163789"/>
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    </ns7:SIO_001279>
    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns0:brs_hasGenomicFeature>
    <ns1:strainDevelopment xml:lang="ja">田中先生がコロンビア大学Rene Hen Labで2007年に作成。田中先生が責任者として自由に配布して良いことになっている。2008年に生理研へ。 CSL3 (129S6由来ES細胞)で作成。</ns1:strainDevelopment>
    <ns9:RO_0002162 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
    <ns1:strainDevelopment xml:lang="ja">田中先生がコロンビア大学Rene Hen Labで2007年に作成。田中先生が責任者として自由に配布して良いことになっている。2008年に生理研へ。CSL3 (129S6由来ES細胞)で作成。</ns1:strainDevelopment>
    <ns5:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr05452'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns5:addinfo>
    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns0:brs_hasGenomicFeature>
    <ns5:termsAndConditions xml:lang="en">In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Biol. Psychiatry, 67, 770-773 (2010).</ns5:termsAndConditions>
    <ns0:brs_hasAllele rdf:resource="http://metadb.riken.jp/db/mgi_rdf/MGI:5439286"/>
    <ns7:SIO_001279 rdf:parseType="Resource">
    </ns7:SIO_001279>
    <ns1:ESCellLine>CSL3[129S6/SvEvTac]</ns1:ESCellLine>
    <ns5:resourceTypeLink rdf:resource="http://metadb.riken.jp/terms/xsearch#resource_type_targeting"/>
    <rdfs:label xml:lang="en">B6.Cg-Nlgn3&lt;tm1.1(tetO)Rhn&gt;</rdfs:label>
    <rdfs:label>B6.Cg-Nlgn3&lt;tm1.1(tetO)Rhn&gt;</rdfs:label>
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    <ns6:organism rdf:parseType="Resource">
    </ns6:organism>
    <ns1:donorDNA>P1 Phage loxP sites, yeast FRT (flipase recombination target) site, E. coli Tetracycline operator site, Cytomegalovirus CMV minimum promoter, mouse Nlgn3 genomic DNA</ns1:donorDNA>
    <skos:altLabel xml:lang="ja">Nlgn3 tetO KI, B6-Nlgn3/tetO KI</skos:altLabel>
    <skos:altLabel xml:lang="en">Nlgn3 tetO KI, B6-Nlgn3/tetO KI</skos:altLabel>
    <ns0:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainType_17"/>
    <dcterms:references rdf:resource="http://identifiers.org/pubmed/20163789"/>
    <ns5:application>Cre/loxP system</ns5:application>
    <dc:description xml:lang="ja">野生型と同等のneuroligin 3の発現を持つ。tTAやtTSによる遺伝子発現制御が可能。</dc:description>
    <ns1:strainDevelopment xml:lang="en">Developed by Kenji Tanaka, Columbia University in 2007. CSL3 ES cells derived from 129S6/SvEvTac were used. FRT-flanked neo selection cassette was removed by crossing with ROSA-Flpe mice. The mutant mice were backcrossed to 129S6 over 5 times. C57BL/6 and 129 mixed background.</ns1:strainDevelopment>
    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns0:brs_hasGenomicFeature>
    <ns1:colonyMaintenance xml:lang="ja">ROSA-Flpeマウスとの交配によりNeoSTOPカセットを除去。その後129S6に5回以上バッククロスしてある。</ns1:colonyMaintenance>
    <ns0:brs_preservationStatus rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainStatus_3"/>
    <ns6:organism rdf:parseType="Resource">
    </ns6:organism>
    <ns1:expectedDelivery xml:lang="en">C (3-6 months)</ns1:expectedDelivery>
    <ns0:brs_depositor xml:lang="ja">田中　謙二</ns0:brs_depositor>
    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns0:brs_hasGenomicFeature>
    <ns1:expectedDelivery xml:lang="ja">C（3〜6か月）</ns1:expectedDelivery>
    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns0:brs_hasGenomicFeature>
    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns0:brs_hasGenomicFeature>
    <dcterms:identifier>RBRC05452</dcterms:identifier>
    <ns5:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns5:addinfo>
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    <ns1:references rdf:parseType="Resource">
    </ns1:references>
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    </ns0:brs_hasGenomicFeature>
    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns0:brs_hasGenomicFeature>
    <rdfs:seeAlso rdf:resource="http://www2.brc.riken.jp/lab/animal/detail.php?brc_no=RBRC05452"/>
    <ns1:isRecombinant rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean"
    >true</ns1:isRecombinant>
    <ns0:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_5"/>
    <ns1:colonyMaintenance xml:lang="en">Homozygote x Hemizygote [or Crossing to C57BL/6JJcl]</ns1:colonyMaintenance>
    <ns5:application>FLP/frt system</ns5:application>
    <ns5:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。Biol. Psychiatry, 67, 770-773 (2010).</ns5:termsAndConditions>
    <ns0:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/straintype_14"/>
    <ns0:brs_depositor xml:lang="en">Kenji TANAKA</ns0:brs_depositor>
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    </ns0:brs_hasGenomicFeature>
    <ns0:brs_preservationStatus rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainStatus_2"/>
    <ns0:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_6"/>
    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns0:brs_hasGenomicFeature>
    <ns5:application>Tet system</ns5:application>
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    </ns0:brs_depositedBy>
  </rdfs:Class>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_17384">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC05452"/>
  </rdf:Description>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_17841">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC05452"/>
  </rdf:Description>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_130019">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC05452"/>
  </rdf:Description>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_18264">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC05452"/>
  </rdf:Description>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015459">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC05452"/>
  </rdf:Description>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_129569">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC05452"/>
  </rdf:Description>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_129108">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC05452"/>
  </rdf:Description>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_130532">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC05452"/>
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_18669">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC05452"/>
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