<rdf:RDF
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:ns5="http://nbrp.jp/ontology/"
    xmlns:ns1="http://metadb.riken.jp/db/rikenbrc_mouse/"
    xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
    xmlns:ns11="http://purl.org/net/cito/"
    xmlns:ns6="http://metadb.riken.jp/db/bioresource_schema/"
    xmlns:ns4="http://metadb.riken.jp/terms/xsearch#"
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:ns9="http://purl.obolibrary.org/obo/"
    xmlns:skos="http://www.w3.org/2004/02/skos/core#"
    xmlns:ns7="http://semanticscience.org/resource/"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#">
  <rdfs:Class rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC05656">
    <ns1:references rdf:parseType="Resource">
    </ns1:references>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns4:addinfo>
    <ns1:references rdf:parseType="Resource">
    </ns1:references>
    <ns6:brs_depositor xml:lang="ja">関口　清俊</ns6:brs_depositor>
    <ns6:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainType_17"/>
    <rdfs:subClassOf rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/Strain"/>
    <rdfs:seeAlso rdf:resource="http://www2.brc.riken.jp/lab/animal/detail.php?brc_no=RBRC05656"/>
    <ns6:brs_depositor xml:lang="en">Kiyotoshi SEKIGUCHI</ns6:brs_depositor>
    <ns1:donorDNA>Bacteriophage P1 loxP sequence</ns1:donorDNA>
    <ns6:brs_preservationStatus rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainStatus_2"/>
    <dcterms:identifier>RBRC05656</dcterms:identifier>
    <dcterms:references rdf:resource="http://identifiers.org/pubmed/15878328"/>
    <ns1:references rdf:parseType="Resource">
    </ns1:references>
    <dc:description xml:lang="en">Qbrick (Frem1) RGD (rg-Gly-Asp) knock-in mice. Exon 4 of Frem1 containing the codon encoding Asp207 was replaced with a mutated exon in which the codon encoding Asp207 was substituted with a codon encoding Glu207.</dc:description>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_4"/>
    <ns1:expectedDelivery xml:lang="en">C (3-6 months)</ns1:expectedDelivery>
    <dcterms:references rdf:resource="http://identifiers.org/pubmed/22613833"/>
    <ns11:citesAsAuthority rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/22613833"/>
    <ns7:SIO_001279 rdf:parseType="Resource">
    </ns7:SIO_001279>
    <ns4:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;利用者は研究成果の公表にあたって謝辞の表明を必要とする。</ns4:termsAndConditions>
    <skos:altLabel xml:lang="ja">Qbrick&lt;RGE&gt;, B6-Frem1/RGE KI</skos:altLabel>
    <skos:altLabel xml:lang="en">Qbrick&lt;RGE&gt;, B6-Frem1/RGE KI</skos:altLabel>
    <ns6:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/straintype_14"/>
    <ns4:application>Cre/loxP system</ns4:application>
    <dc:description xml:lang="ja">Qbrick (Frem1) ゲノム上のArg-Gly-Asp (RGD) 配列をコードする部分がArg-Gly-Glu (RGE) となるよう変異を挿入したマウス。Qbrickは基底膜分子であり、インテグリン結合モチーフであるArg-Gly-Asp (RGD) 配列を有する。RGE変異配列にはインテグリン結合活性はない。</dc:description>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns1:strainDevelopment xml:lang="ja">大阪大学蛋白質研究所・関口清俊（2012）。129系統由来ES細胞を用いて作製。C57BL/6Jマウスと交配された。</ns1:strainDevelopment>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns6:brs_depositedBy rdf:parseType="Resource">
    </ns6:brs_depositedBy>
    <ns4:termsAndConditions xml:lang="en">In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.</ns4:termsAndConditions>
    <ns6:brs_preservationStatus rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainStatus_3"/>
    <ns1:expectedDelivery xml:lang="ja">C（3〜6か月）</ns1:expectedDelivery>
    <ns5:organism rdf:parseType="Resource">
    </ns5:organism>
    <ns1:references rdf:parseType="Resource">
    </ns1:references>
    <ns4:resourceTypeLink rdf:resource="http://metadb.riken.jp/terms/xsearch#resource_type_targeting"/>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_8"/>
    <ns6:brs_depositedBy rdf:parseType="Resource">
    </ns6:brs_depositedBy>
    <rdfs:label>B6;129-Frem1&lt;tm2.1Ksek&gt;</rdfs:label>
    <rdfs:label xml:lang="en">B6;129-Frem1&lt;tm2.1Ksek&gt;</rdfs:label>
    <ns4:application>Cell Biology Research</ns4:application>
    <ns6:brs_hasAllele rdf:resource="http://metadb.riken.jp/db/mgi_rdf/MGI:5427907"/>
    <ns1:strainDevelopment xml:lang="en">Developed by Kiyotoshi Sekiguchi, Institute for Protein Research, Osaka University in 2012. 129 derived ES cells were used.  The mutant mice were crossed to C57BL/6J. A floxed neo cassette was removed by cre-mediated recombination.</ns1:strainDevelopment>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns1:colonyMaintenance xml:lang="ja">Heterozygote x Wild-type [C57BL/6JJmsSlc]</ns1:colonyMaintenance>
    <ns1:colonyMaintenance xml:lang="en">Heterozygote x Wild-type [C57BL/6JJmsSlc]</ns1:colonyMaintenance>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns1:isRecombinant rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean"
    >true</ns1:isRecombinant>
    <ns5:organism rdf:parseType="Resource">
    </ns5:organism>
    <ns11:citesAsAuthority rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/15878328"/>
    <ns7:SIO_001279 rdf:parseType="Resource">
    </ns7:SIO_001279>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_6"/>
    <ns9:RO_0002162 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
  </rdfs:Class>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_130892">
    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC05656"/>
  </rdf:Description>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1008574">
    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC05656"/>
  </rdf:Description>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_1702">
    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC05656"/>
  </rdf:Description>
</rdf:RDF>