Mouse Spry2 genomic DNA, Mouse Phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene RBRC05756 B6.Cg-Spry2<tm1Ayos> B6.Cg-Spry2<tm1Ayos> Developed by Akihiko Yoshimura, Medical Institute of Bioregulation, Kyushu University. Sprouty2 KO, B6-Spry2 KO Sprouty2 KO, B6-Spry2 KO In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Neurosci., 8 ,855-857 (2005).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. true 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Nat. Neurosci., 8 ,855-857 (2005).<br>研究成果の公表にあたって謝辞の表明を必要とする。 C (3-6 months) Neurobiology Research Sprouty2 (Spry2) 遺伝子のノックアウトマウス。エクソン2をPGK-neoカセットで置換。ホモマウスは腸管神経形成異常となり、食道無弛緩症、腸偽閉塞を呈する。ホモマウスは生後6週間以内に約半数が死亡する。, Sprouty2 (Spry2) gene knockout mice. Exon 2 was replaced with a PGK-neo cassette. Homozygous mutant mice exhibit enteric nerve hyperplasia. About half of homozygotes die within 6 weeks after birth. Sprouty2 (Spry2) 遺伝子のノックアウトマウス。エクソン2をPGK-neoカセットで置換。ホモマウスは腸管神経形成異常となり、食道無弛緩症、腸偽閉塞を呈する。ホモマウスは生後6週間以内に約半数が死亡する。 吉村　昭彦 Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> Akihiko YOSHIMURA 九州大学生体防御医学研究所・吉村昭彦先生。 Heterozygote x Wild-type [C57BL/6JJcl] Heterozygote x Wild-type [C57BL/6JJcl] C（3〜6か月）