C(3〜6か月) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 283, :33858-33864 (2008).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. true Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> FLN29 (Trafd1) 遺伝子のノックアウトマウス。エクソン2と3をPGK-neoカセットで置換。ホモマウスはLPS endotoxin shockに対し、感受性が増加し、VSV (水疱性口内炎ウイルス) 感染に対する感受性が減少する。 Akihiko YOSHIMURA Immunology and Inflammation Research FLN29 (Trafd1) gene knockout mice. Homozygous mutant mice exhibit increased susceptibility to LPS-endotoxin shock and decreased susceptibility to VSV infection. FLN29, B6-Trafd1 KO FLN29, B6-Trafd1 KO <a href='https://brc.riken.jp/mus/pcr05762'>Genotyping protocol -PCR-</a> FLN29 (Trafd1) 遺伝子のノックアウトマウス。エクソン2と3をPGK-neoカセットで置換。ホモマウスはLPS endotoxin shockに対し、感受性が増加し、VSV (水疱性口内炎ウイルス) 感染に対する感受性が減少する。, Cell Biology Research 吉村 昭彦 Heterozygote x Wild-type [C57BL/6JJcl] Heterozygote x Wild-type [C57BL/6JJcl] C (3-6 months) mouse Phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, mouse Trafd1 genomic DNA Developed by Akihiko Yoshimura, Medical Institute of Bioregulation, Kyushu University. 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。J. Biol. Chem., 283, :33858-33864 (2008).<br>研究成果の公表にあたって謝辞の表明を必要とする。 B6.Cg-Trafd1<tm1Ayos> B6.Cg-Trafd1<tm1Ayos> RBRC05762 九州大学生体防御医学研究所・吉村昭彦先生。