長寿医療研究センター研究所・橋本有弘先生（2004）。C57BL/6背景（戻し交配8年）。 Naohiro HASHIMOTO 条件を付加しない。 Developed by Naohiro Hashimoto, National Center for Geriatrics and Gerontology in 2004. The mutant mice were backcrossed to C57BL/6. Diabetes and Obesity Research <a href='https://brc.riken.jp/mus/pcr06192'>Genotyping protocol -PCR-</a> mouse phosphoglycerate kinase promoter (PGK promoter), Klebsiella pneumoniae neomycin resistance gene, mouse Trib3 genomic DNA No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) RBRC06192 B6.129-Trib3<tm1Nah> B6.129-Trib3<tm1Nah> B (1-3 months) 橋本　有弘 Nudin1-KO, B6-Trib3 KO Nudin1-KO, B6-Trib3 KO Homozygote x Homozygote [or Crossing to C57BL/6JJcl] Homozygote x Homozygote [or Crossing to C57BL/6JJcl] covid19_progression B（1〜3か月） Nudin1 (Trib3) gene knockout mice. Homozygous mutant mice show no obvious abnormality. true Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> Nudin1 (Trib3) 遺伝子のノックアウトマウス。Nudin1は、protein kinase domainに似た配列 (psuedokinase domain) を有するタンパク質。Aktの阻害因子として作用し、GSK2betaを介してinsulin抵抗性に関与すると報告された。しかし、その後相反する結果が報告され、その機能には不明の点が多い。ホモマウスは目立った異常は認められない。