ZIP13 KO, B6-Slc39a13 KO ZIP13 KO, B6-Slc39a13 KO mouse phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, mouse Slc39a13 genomic DNA Zip13 (Slc39a13) gene knockout mice. Exons 6 through 8 were replaced with a neo cassette. RBRC06217 理化学研究所・免疫アレルギー科学総合研究センター（2008）。R1 ES細胞由来。 Dermatology Research C（3〜6か月） R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] Developmental Biology Research Zip13 (Slc39a13) 遺伝子のノックアウトマウス。エクソン6から8をneoカセットで置換。Zip13は、Slc39/ZIPファミリー亜鉛トランスポーターに属し、主に骨芽細胞／軟骨細胞／象牙芽細胞／線維芽細胞等に発現する。Zip13遺伝子の機能を阻害すると、ホモマウスは生後2-3週齢から成長遅延を呈し、骨形成不全・皮膚脆弱化・顔面特徴の変化・歯牙形成不全等を現す。これはBMP/TGF-βのシグナル伝達系の支障が原因の一つと考えられている。骨や歯の形成および皮膚代謝の研究に有用であり、本マウスはSpondylodysplastic Ehlers-Danlos症候群のモデルマウスである。 C (3-6 months) true Toshiyuki FUKADA 条件を付加する。利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。PLoS One. 2008 3(11):e3642. B6;129-Slc39a13<tm1Thir> B6;129-Slc39a13<tm1Thir> <a href='https://brc.riken.jp/mus/pcr06217'>Genotyping protocol -PCR-</a> Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. PLoS One. 2008 3(11):e3642. Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> Developed by Toshiyuki Fukuda, RIKEN Center for Allergy and Immunology in 2008. R1 ES cells derived from (129X1/SvJ x 129S1/Sv)F1-Kitl<+> were used for the generation of knockout mice. The mutant mice were crossed to C57BL/6J. Heterozygote x Wild-type [C57BL/6JJcl] Heterozygote x Wild-type [C57BL/6JJcl] 小安　重夫 深田　俊幸 Shigeo KOYASU Mouse Models for Human Disease