<rdf:RDF
    xmlns:ns4="http://metadb.riken.jp/terms/xsearch#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:ns5="http://nbrp.jp/ontology/"
    xmlns:ns1="http://metadb.riken.jp/db/rikenbrc_mouse/"
    xmlns:skos="http://www.w3.org/2004/02/skos/core#"
    xmlns:ns7="http://semanticscience.org/resource/"
    xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
    xmlns:ns10="http://purl.org/net/cito/"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
    xmlns:ns6="http://metadb.riken.jp/db/bioresource_schema/">
  <rdfs:Class rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC06389">
    <ns1:colonyMaintenance xml:lang="ja">Homozygote x Homozygote [or Crossing to C57BL/6JJcl]</ns1:colonyMaintenance>
    <ns7:SIO_001279 rdf:parseType="Resource">
    </ns7:SIO_001279>
    <ns1:colonyMaintenance xml:lang="en">Homozygote x Homozygote [or Crossing to C57BL/6JJcl]</ns1:colonyMaintenance>
    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Approval form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;&lt;A HREF="https://www.bioreg.kyushu-u.ac.jp/saibou/index_en.html" target="_blank"&gt;Lab HP&lt;/A&gt;</ns4:addinfo>
    <ns10:citesAsAuthority rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/23452856"/>
    <ns5:organism rdf:parseType="Resource">
    </ns5:organism>
    <ns4:resourceTypeLink rdf:resource="http://metadb.riken.jp/terms/xsearch#resource_type_targeting"/>
    <rdfs:label>B6;129P2-Fbxl3&lt;tm1Kei&gt;</rdfs:label>
    <rdfs:label xml:lang="en">B6;129P2-Fbxl3&lt;tm1Kei&gt;</rdfs:label>
    <ns1:references rdf:parseType="Resource">
    </ns1:references>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns4:application>Fluorescent Proteins/lacZ System</ns4:application>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns6:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainType_17"/>
    <ns7:SIO_001279 rdf:parseType="Resource">
    </ns7:SIO_001279>
    <ns6:brs_depositor xml:lang="ja">中山　敬一</ns6:brs_depositor>
    <ns1:isRecombinant rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean"
    >true</ns1:isRecombinant>
    <dc:description xml:lang="en">Fbxl3 gene knockout mice.  Exons 2 and 3 were replaced with an IRES-lacZ/neo cassette.</dc:description>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <rdfs:subClassOf rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/Strain"/>
    <ns4:application>Metabolism Research</ns4:application>
    <rdfs:seeAlso rdf:resource="http://www2.brc.riken.jp/lab/animal/detail.php?brc_no=RBRC06389"/>
    <ns4:termsAndConditions xml:lang="ja">条件を付加する。利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。&lt;br&gt;共同研究。</ns4:termsAndConditions>
    <ns1:expectedDelivery xml:lang="en">D (more than 6 months)</ns1:expectedDelivery>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns1:expectedDelivery xml:lang="ja">D（6か月以上）</ns1:expectedDelivery>
    <ns1:ESCellLine>E14 [129P2/OlaHsd]</ns1:ESCellLine>
    <ns1:strainDevelopment xml:lang="ja">九州大学生体防御医学研究所・中山敬一先生。E14 ES細胞を用いて作出。C57BL/6Jへ交配された（N7世代）。</ns1:strainDevelopment>
    <ns6:brs_depositor xml:lang="en">Keiichi NAKAYAMA</ns6:brs_depositor>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns1:donorDNA>E. coli Neomycin resistance gene, mouse phosphoglycerate kinase promoter, SV40 polyA signal, ECMV internal ribosomal entry site (ires), E. coli lacZ, phage P1 loxP</ns1:donorDNA>
    <ns1:strainDevelopment xml:lang="en">Developed by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University.  E14 ES cells were used.  The mutant mice were crossed to C57BL/6J (N7 generations).</ns1:strainDevelopment>
    <ns6:brs_depositedBy rdf:parseType="Resource">
    </ns6:brs_depositedBy>
    <dcterms:references rdf:resource="http://identifiers.org/pubmed/23452856"/>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <dc:description xml:lang="ja">Fbxl3遺伝子のノックアウトマウス。エクソン2と3をIRES-lacZ/neoカセットで置換。Fbxl3はSCF型ユビキチンリガーゼSCF&lt;Fbxl3&gt;のF-boxタンパク質サブユニットである。SCF&lt;Fbxl3&gt;は概日時計中枢において中心的な役割を果たすCRYタンパク質のユビキチン化依存的分解に関わっており、Fbxl3遺伝子の機能を阻害すると、恒暗条件下での概日リズムの延長を呈する。</dc:description>
    <ns4:application>Cre/loxP system</ns4:application>
    <dcterms:identifier>RBRC06389</dcterms:identifier>
    <ns6:brs_preservationStatus rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainStatus_2"/>
    <ns6:brs_hasAllele rdf:resource="http://metadb.riken.jp/db/mgi_rdf/MGI:5503966"/>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_3"/>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns7:SIO_001279 rdf:parseType="Resource">
    </ns7:SIO_001279>
    <ns4:termsAndConditions xml:lang="en">Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.</ns4:termsAndConditions>
    <skos:altLabel xml:lang="en">Fbxl3 KO, B6-Fbxl3 KO</skos:altLabel>
    <skos:altLabel xml:lang="ja">Fbxl3 KO, B6-Fbxl3 KO</skos:altLabel>
    <ns6:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/straintype_14"/>
  </rdfs:Class>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1019893">
    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC06389"/>
  </rdf:Description>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1019892">
    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC06389"/>
  </rdf:Description>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020363">
    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC06389"/>
  </rdf:Description>
</rdf:RDF>