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    <ns10:citesAsAuthority rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/17657313"/>
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    <ns4:termsAndConditions xml:lang="en">The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Biotechnol., 19, 746-750 (2001).  J. Clin Invest., 117, 2268-2278 (2007).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR/DEVELOPER (Masato Tanaka, Ph.D. and Kenji Kohno, Ph.D.) is requested.</ns4:termsAndConditions>
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    <ns1:expectedDelivery xml:lang="en">D (more than 6 months)</ns1:expectedDelivery>
    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Approval form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns4:addinfo>
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    <ns6:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainType_17"/>
    <ns6:brs_depositor xml:lang="en">Masato TANAKA</ns6:brs_depositor>
    <dcterms:identifier>RBRC06408</dcterms:identifier>
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    <ns4:termsAndConditions xml:lang="ja">条件を付加する。利用者は事前に寄託者の提供承諾書を得る。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。Nat. Biotechnol., 19, 746-750 (2001).  J. Clin Invest., 117, 2268-2278 (2007).&lt;br&gt;研究成果の公表にあたっては、寄託者/開発者（Masato Tanaka, Ph.D.およびKenji Kohno, Ph.D.）へ謝辞の表明を必要とする。</ns4:termsAndConditions>
    <ns1:ESCellLine>R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl&lt;+&gt;]</ns1:ESCellLine>
    <ns6:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/straintype_14"/>
    <ns1:colonyMaintenance xml:lang="en">Homozygote x Homozygote [or Crossing to BALB/cAJcl]</ns1:colonyMaintenance>
    <ns1:colonyMaintenance xml:lang="ja">Homozygote x Homozygote [or Crossing to BALB/cAJcl]</ns1:colonyMaintenance>
    <ns6:brs_hasAllele rdf:resource="http://metadb.riken.jp/db/mgi_rdf/MGI:3720841"/>
    <ns1:expectedDelivery xml:lang="ja">D（6か月以上）</ns1:expectedDelivery>
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    <dc:description xml:lang="ja">CD169 (Siglec1) 遺伝子プロモーター下流にヒトジフテリア毒素受容体 (DTR) であるHB-EGF遺伝子を挿入したマウス。ジフテリア毒素 (DT) 投与により脾臓辺縁帯およびリンパ洞に局在するマクロファージ (CD169陽性マクロファージ) が消失する。</dc:description>
    <skos:altLabel xml:lang="en">CD169-DTR, BALB-Siglec1/DTR KI</skos:altLabel>
    <skos:altLabel xml:lang="ja">CD169-DTR, BALB-Siglec1/DTR KI</skos:altLabel>
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    >true</ns1:isRecombinant>
    <ns1:strainDevelopment xml:lang="en">Developed by Masato Tanaka, RIKEN Research Center for Allergy and Immunology.  R1 ES cells were used.  The mutant mice were crossed to BALB/c over 5 times.</ns1:strainDevelopment>
    <dc:description xml:lang="en">CD169 (Siglec1) DTR knock-in mice.  HB-EGF is expressed from CD169 locus.</dc:description>
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    <ns4:application>Cre/loxP system</ns4:application>
    <ns6:brs_depositor xml:lang="ja">田中　正人</ns6:brs_depositor>
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    <rdfs:label>C;129(B6)-Siglec1&lt;tm1(HBEGF)Mtka&gt;</rdfs:label>
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    <ns1:strainDevelopment xml:lang="ja">理化学研究所免疫・アレルギー科学総合研究所・田中正人先生。R1 ES細胞を用いて作出。BALB/cへ戻し交配された（5世代以上）。</ns1:strainDevelopment>
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    <ns1:donorDNA>Human HB-EGF(DTR) cDNA, Phage P1 loxP site, Mouse Siglec1 genomic DNA</ns1:donorDNA>
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