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    <skos:altLabel xml:lang="ja">Cyclon-Tg(B)</skos:altLabel>
    <skos:altLabel xml:lang="en">Cyclon-Tg(B)</skos:altLabel>
    <dc:description xml:lang="en">Transgenic mouse line expressing mouse Ccdc86 (coiled-coil domain containing 86, Cyclon) under the control of human CD2 promoter. Both T and B lymphocytes express transgene. Tg mice exhibited elevation of Fas expression in activated T lyphocytes.</dc:description>
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    <ns4:termsAndConditions xml:lang="en">In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.  Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon. Saint Fleur S, Hoshino A, Kondo K, Egawa T, Fujii H. Blood (2009) 114 (7): 1355-65. The BIOLOGICAL RESOURCE shall be used only for academic research purposes by not-for-profit institutions. Use of the BIOLOGICAL RESOURCE by for-profit institutions or use for commercial research purposes shall require a commercial license from the Depositor. A recipient shall also acquire a prior written consent from the Depositor  prior to filing an application for a patent, or intellectual  property or other rights based on the results of their use of the  BIOLOGICAL RESOURCE.</ns4:termsAndConditions>
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    <rdfs:label>B6.FVB-Tg(CD2-Ccdc86)1Hfuj</rdfs:label>
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    <dc:description xml:lang="ja">ヒトCD2プロモーター制御下で、マウスCcdc86 (coiled-coil domain containing 86, 別名Cyclon) をリンパ球特異的に発現するトランスジェニックマウス。T細胞だけでなく、B細胞にもトランスジーンの発現が認められる。活性化T細胞におけるFas蛋白質の発現が亢進している。</dc:description>
    <ns1:expectedDelivery xml:lang="en">D (more than 6 months)</ns1:expectedDelivery>
    <dcterms:identifier>RBRC09602</dcterms:identifier>
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    </ns6:brs_hasGenomicFeature>
    <ns4:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.  Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon. Saint Fleur S, Hoshino A, Kondo K, Egawa T, Fujii H. Blood (2009) 114 (7): 1355-65. The BIOLOGICAL RESOURCE shall be used only for academic research purposes by not-for-profit institutions. Use of the BIOLOGICAL RESOURCE by for-profit institutions or use for commercial research purposes shall require a commercial license from the Depositor. A recipient shall also acquire a prior written consent from the Depositor  prior to filing an application for a patent, or intellectual  property or other rights based on the results of their use of the  BIOLOGICAL RESOURCE.</ns4:termsAndConditions>
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    <ns1:strainDevelopment xml:lang="en">Developed by Hodaka Fujii, New York University in 2009. A DNA construct was injected to fertilized eggs derived from FVB/N.  Mice were backcrossed to C57BL/6 background for at least 6 generations.</ns1:strainDevelopment>
    <ns1:expectedDelivery xml:lang="ja">D（6か月以上）</ns1:expectedDelivery>
    <ns1:donorDNA>ヒト CD2遺伝子、5 kbp プロモーター, ヒト　インフルエンザウイルス ヘマグルチニンタグ, マウス Cyclon蛋白質遺伝子, ヒト CD2遺伝子、5.5 kbp Locus Control Region (LCR)</ns1:donorDNA>
    <ns1:strainDevelopment xml:lang="ja">開発者／機関：藤井　穂高／ニューヨーク大学。開発年：2009年。FVB/N系統の受精卵を使用。C57BL/6へ少なくとも6回交配。</ns1:strainDevelopment>
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    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns4:addinfo>
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