Neurobiology Research D (more than 6 months) DAL101 mice DAL101 mice Developed by Shigeo Ohta, Nippon Medical School in 2009. A transgenic construct was injected into fertilized eggs derived from C57BL/6. This line was maintained in C57BL/6N background. Dominant negativeにALDH2の活性が低下するマウス。脳の酸化ストレスが亢進することに起因する認知機能障害モデルマウス 日本医科大学 太田成男(2009)兄弟交配によりホモで維持していた。 true 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。J. Neurosci., 28, 6239-6249 (2008).<br>研究成果の公表にあたって謝辞の表明を必要とする。<br>学術機関の学術研究に限る。利用者が本件のリソースを使用して得られた研究成果に基づき特許等の申請、及び事業活動を行う場合は、寄託者と別途協議を行う。 C57BL/6-Tg(EIF1AX-Aldh2<*>E504K)101Oht C57BL/6-Tg(EIF1AX-Aldh2<*>E504K)101Oht Transgenic mice overexpressing mutated Aldh2 (E504K) under the control of the human EF1a promoter. This mutated Aldh2 acts in a dominant-negative manner. D(6か月以上) 日本医科大学 太田成男(2009) 兄弟交配によりホモで維持していた。 Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 28, 6239-6249 (2008).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. RBRC09897 Mouse 改変型ALDH2,Human G-CSF cDNA PolyA signal, Human EF1a promoter