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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID1h3h  sequence information (FASTA format)   
DescriptorGRB2-RELATED ADAPTOR PROTEIN 2, LYMPHOCYTE CYTOSOLIC PROTEIN 2
TitleSTRUCTURAL BASIS FOR SPECIFIC RECOGNITION OF AN RXXK-CONTAINING SLP-76 PEPTIDE BY THE GADS C-TERMINAL SH3 DOMAIN
Functional KeywordsPROTEIN-BINDING, COMPLEX (SH3/PEPTIDE), T-CELL SIGNALING, SH3 DOMAIN, SH2 DOMAIN
Biological sourceMUS MUSCULUS (MOUSE) ,HOMO SAPIENS (HUMAN) (the details in Structural Details Page)
Cellular location [UNP - Q9QUG9] Cytoplasm, cytosol (By similarity)
Organ source [UNP - Q9QUG9] Mammary gland
[UNP - Q9QUG9] Embryo
[UNP - Q9QUG9] Liver
Total number of polymer chains2
Total molecular weight8093.2 (the details in Structural Details Page)
AuthorsLiu, Q. , Berry, D. , Nash, P. , Pawson, T. , Mcglade, C.J. , Li, S.S. (deposition date : 2002-09-03, release date : 2003-03-06)
Primary citationLiu, Q. , Berry, D. , Nash, P. , Pawson, T. , Mcglade, C.J. , Li, S.S.C.
Structural Basis for Specific Binding of the Gads SH3 Domain to an Rxxk Motif-Containing Slp-76 Peptide: A Novel Mode of Peptide Recognition
Mol.Cell, 11:471 - , 2003.(PubMed : 12620234)  (DOI: 10.1016/S1097-2765(03)00046-7)
Experimental methodSOLUTION NMR
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q9QUG9, Q13094 ) , eF-site , PISA , NRG-CING