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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID1iiq  sequence information (FASTA format)   
RELATED PDB ID1fqx
DescriptorPROTEASE RETROPEPSIN (E.C.3.4.23.16), PEPTIDE INHIBITOR
TitleCRYSTAL STRUCTURE OF HIV-1 PROTEASE COMPLEXED WITH A HYDROXYETHYLAMINE PEPTIDOMIMETIC INHIBITOR
Functional KeywordsHIV, protease, inhibitor, peptidomimetics, HYDROLASE, HYDROLASE INHIBITOR
Biological sourceHuman immunodeficiency virus 1
Cellular location [UNP - P03367] Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential)
Total number of polymer chains3
Total molecular weight22753.9 (the details in Structural Details Page)
AuthorsDohnalek, J. , Hasek, J. , Duskova, J. , Petrokova, H. , Hradilek, M. , Soucek, M. , Konvalinka, J. , Brynda, J. , Sedlacek, J. , Fabry, M. (deposition date : 2001-04-24, release date : 2002-04-12)
Primary citationDohnalek, J. , Hasek, J. , Duskova, J. , Petrokova, H. , Hradilek, M. , Soucek, M. , Konvalinka, J. , Brynda, J. , Sedlacek, J. , Fabry, M.
Hydroxyethylamine isostere of an HIV-1 protease inhibitor prefers its amine to the hydroxy group in binding to catalytic aspartates. A synchrotron study of HIV-1 protease in complex with a peptidomimetic inhibitor.
J.Med.Chem., 45:1432 - 1438, 2002.(PubMed : 11906284)  (DOI: 10.1021/jm010979e)
Experimental methodX-RAY DIFFRACTION ( 1.83[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P03367 ) , eF-site , KEGG ( EC 3.4.23.16 ) , PISA