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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID1iyt  sequence information (FASTA format)   
DescriptorAlzheimer's disease amyloid A4 protein
TitleSolution structure of the Alzheimer's disease amyloid beta-peptide (1-42)
Functional KeywordsAmyloid beta-peptide, Alzheimers disease, helix-kink-helix, PROTEIN BINDING
Biological source [UNP - P05067] Homo sapiens (Human)
Cellular location [UNP - P05067] Membrane; Single-pass type I membrane protein
Organ source [UNP - P05067] Brain
[UNP - P05067] Leukocyte
[UNP - P05067] Eye, and Pancreas
[UNP - P05067] Liver
[UNP - P05067] Fibroblast
[UNP - P05067] Platelet
[UNP - P05067] Brain cortex
[UNP - P05067] Blood vessel
[UNP - P05067] Cerebrospinal fluid
[UNP - P05067] Fetal brain
[UNP - P05067] Plasma
Total number of polymer chains1
Total molecular weight4520.1 (the details in Structural Details Page)
AuthorsCrescenzi, O. , Tomaselli, S. , Guerrini, R. , Salvadori, S. , D'Ursi, A.M. , Temussi, P.A. , Picone, D. (deposition date : 2002-09-06, release date : 2003-02-11)
Primary citationCrescenzi, O. , Tomaselli, S. , Guerrini, R. , Salvadori, S. , D'Ursi, A.M. , Temussi, P.A. , Picone, D.
Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain.
Eur. J. Biochem., 269:5642 - 5648, 2002.(PubMed : 12423364)  (DOI: 10.1046/j.1432-1033.2002.03271.x)
Experimental methodSOLUTION NMR
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P05067 ) , eF-site , PISA , NRG-CING