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Summary [1kf9]

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PDB ID or Keywordsequenceauthor name

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<Asymmetric unit> More images... View in 3D molecule viewer ( jV3 / Jmol ) *1 <Biological unit> View in 3D molecule viewer ( jV3 ) *1

PDB ID 1kf9  sequence information (FASTA format)    Descriptor PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE, EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238) Title PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR Functional Keywords CYTOKINE, HORMONE-RECEPTOR COMPLEX, PHAGE DISPLAY MOLECULAR PLASTICITY, RECEPTOR HOMODIMERIZATION, HUMAN GROWTH HORMONE, HORMONE/GROWTH FACTOR COMPLEX Biological source Homo sapiens (human) Cellular location [UNP - P10912] Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Growth hormone-binding protein: Secreted Organ source [UNP - P10912] Liver [UNP - P10912] Placenta Total number of polymer chains 6 Total molecular weight 153613.6 (the details in Structural Details Page) Authors Schiffer, C.A. , Ultsch, M. , Walsh, S. , Somers, W. , De Vos, A.M. , Kossiakoff, A.A. (deposition date : 2001-11-19, release date : 2002-11-20) Primary citation Schiffer, C.A. , Ultsch, M. , Walsh, S. , Somers, W. , De Vos, A.M. , Kossiakoff, A.A. Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites J. Mol. Biol., 316:277 - 289, 2002.(PubMed : 11851338)  (DOI: 10.1006/jmbi.2001.5348) Experimental method X-RAY DIFFRACTION ( 2.60[Å] ) Other Database Information EM Navigator , Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P10912 ) , eF-site , GDB , ProTherm , EzCatDB , PISA , PQS

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