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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID1kxr  sequence information (FASTA format)   
RELATED PDB ID1df0, 1kfu, 1kfx, 1dvi, 1aj5, 1alw
Descriptorthiol protease DOMAINS I AND II (E.C.3.4.22.17)
TitleCrystal Structure of Calcium-Bound Protease Core of Calpain I
Functional KeywordsPAPAIN-RELATED, CALCIUM-DEPENDENT CYSTEINE PROTEASE, TWO NOVEL COOPERATIVE CALCIUM SITES, HYDROLASE
Biological sourceRattus norvegicus (Norway rat)
Cellular location [UNP - P97571] Cytoplasm (By similarity)
Organ source [UNP - P97571] Prostate
Total number of polymer chains2
Total molecular weight77738 (the details in Structural Details Page)
AuthorsMoldoveanu, T. , Hosfield, C.M. , Lim, D. , Elce, J.S. , Jia, Z. , Davies, P.L. (deposition date : 2002-02-01, release date : 2002-03-20)
Primary citationMoldoveanu, T. , Hosfield, C.M. , Lim, D. , Elce, J.S. , Jia, Z. , Davies, P.L.
A Ca(2+) switch aligns the active site of calpain.
Cell(Cambridge,Mass.), 108:649 - 660, 2002.(PubMed : 11893336)  (DOI: 10.1016/S0092-8674(02)00659-1)
Experimental methodX-RAY DIFFRACTION ( 2.07[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P97571 ) , eF-site , KEGG ( EC 3.4.22.17 ) , PISA