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MineSummary [1b6m]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID1b6m  sequence information (FASTA format)   
RELATED PDB ID1b6j, 1b6k, 1b6l, 1b6n, 1b6o, 1b6p
DescriptorRETROPEPSIN (E.C.3.4.23.16)
TitleHIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 6
Functional KeywordsCOMPLEX (ACID PROTEINASE/PEPTIDE), HYDROLASE/HYDROLASE INHIBITOR COMPLEX
Biological sourceHuman immunodeficiency virus 1
Cellular location [UNP - P03369] Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential)
Total number of polymer chains2
Total molecular weight22416.7 (the details in Structural Details Page)
AuthorsMartin, J.L. , Begun, J. , Schindeler, A. , Wickramasinghe, W.A. , Alewood, D. , Alewood, P.F. , Bergman, D.A. , Brinkworth, R.I. , Abbenante, G. , March, D.R. , Reid, R.C. , Fairlie, D.P. (deposition date : 1999-01-17, release date : 2000-01-07)
Primary citationMartin, J.L. , Begun, J. , Schindeler, A. , Wickramasinghe, W.A. , Alewood, D. , Alewood, P.F. , Bergman, D.A. , Brinkworth, R.I. , Abbenante, G. , March, D.R. , Reid, R.C. , Fairlie, D.P.
Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38:7978 - 7988, 1999.(PubMed : 10387041)  (DOI: 10.1021/bi990174x)
Experimental methodX-RAY DIFFRACTION ( 1.85[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P03369 ) , eF-site , KEGG ( EC 3.4.23.16 ) , PISA