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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID1lvo  sequence information (FASTA format)   
DescriptorHydrolase
TitleStructure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain
Functional Keywords3C like, corona, proteinase, chymotrypsin, cysteine histidine dyad, beta barrel, HYDROLASE
Biological sourceTransmissible gastroenteritis virus
Cellular location [UNP - P0C6Y5] Non-structural protein 3: Membrane; Multi- pass membrane protein (Potential). Non-structural protein 4: Membrane; Multi- pass membrane protein (Potential). Non-structural protein 6: Membrane; Multi- pass membrane protein (Potential). Non-structural protein 7: Cytoplasm, perinuclear region (By similarity). Non-structural protein 8: Cytoplasm, perinuclear region (By similarity). Non-structural protein 9: Cytoplasm, perinuclear region (By similarity). Non-structural protein 10: Cytoplasm, perinuclear region (By similarity). Helicase: Endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Cytoplasm, perinuclear region (By similarity)
Total number of polymer chains6
Total molecular weight202838.4 (the details in Structural Details Page)
AuthorsAnand, K. , Palm, G.J. , Mesters, J.R. , Siddell, S.G. , Ziebuhr, J. , Hilgenfeld, R. (deposition date : 2002-05-29, release date : 2002-07-17)
Primary citationAnand, K. , Palm, G.J. , Mesters, J.R. , Siddell, S.G. , Ziebuhr, J. , Hilgenfeld, R.
Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain.
EMBO J., 21:3213 - 3224, 2002.(PubMed : 12093723)  (DOI: 10.1093/emboj/cdf327)
Experimental methodX-RAY DIFFRACTION ( 1.96[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P0C6Y5 ) , eF-site , PISA