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MineSummary [1o77]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>

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PDB ID1o77  sequence information (FASTA format)   
RELATED PDB ID1fyw
DescriptorTOLL-LIKE RECEPTOR 2
TitleCRYSTAL STRUCTURE OF THE C713S MUTANT OF THE TIR DOMAIN OF HUMAN TLR2
Functional KeywordsIMMUNE SYSTEM/MEMBRANE PROTEIN, KNOWN BIOLOGICAL ACTIVITY RECEPTOR, IMMUNE RESPONSE, INFLAMMATORY RESPONSE, SIGNAL, TRANSMEMBRANE, REPEAT, LEUCINE-RICH REPEAT, GLYCOPROTEIN, 3D-STRUCTURE.
Biological sourceHOMO SAPIENS (HUMAN)
Cellular location [UNP - O60603] Membrane; Single-pass type I membrane protein (By similarity)
Organ source [UNP - O60603] Leukocyte, and Prostate
[UNP - O60603] Fetal lung
[UNP - O60603] Blood
Total number of polymer chains5
Total molecular weight87621.5 (the details in Structural Details Page)
AuthorsTao, X. , Xu, Y. , Ye, Z. , Beg, A.A. , Tong, L. (deposition date : 2002-10-24, release date : 2002-11-21)
Primary citationTao, X. , Xu, Y. , Zheng, Y. , Beg, A.A. , Tong, L.
An Extensively Associated Dimer in the Structure of the C713S Mutant of the Tir Domain of Human Tlr2
Biochem.Biophys.Res.Commun., 299:216 - 221, 2002.(PubMed : 12437972)  (DOI: 10.1016/S0006-291X(02)02581-0)
Experimental methodX-RAY DIFFRACTION ( 3.2[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( O60603 ) , eF-site , PISA