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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID2gab  sequence information (FASTA format)   
DescriptorTransthyretin
TitleHuman Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-3,3',5,4'-tetrachlorobiphenyl
Functional KeywordsTTR, AMYLOID, TRANSTHYRETIN, HORMONE/GROWTH FACTOR COMPLEX
Biological sourceHomo sapiens (human)
Cellular location [UNP - P02766] Secreted
Organ source [UNP - P02766] Liver
[UNP - P02766] Platelet
[UNP - P02766] Brain, Cajal-Retzius cell, and Fetal brain cortex
[UNP - P02766] Plasma
[UNP - P02766] Cerebrospinal fluid
Total number of polymer chains2
Total molecular weight28171 (the details in Structural Details Page)
AuthorsPalaninathan, S.K. , Smith, C. , Safe, S.H. , Kelly, J.W. , Sacchettini, J.C. (deposition date : 2006-03-08, release date : 2006-03-21)
Primary citationPurkey, H.E. , Palaninathan, S.K. , Kent, K.C. , Smith, C. , Safe, S.H. , Sacchettini, J.C. , Kelly, J.W.
Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity
Chem.Biol., 11:1719 - 1728, 2004.(PubMed : 15610856)  (DOI: 10.1016/j.chembiol.2004.10.009)
Experimental methodX-RAY DIFFRACTION ( 1.85[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P02766 ) , eF-site , PISA