PDB ID 2gab sequence information (FASTA format)
Descriptor Transthyretin
Title Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-3,3',5,4'-tetrachlorobiphenyl
Functional Keywords TTR, AMYLOID, TRANSTHYRETIN, HORMONE/GROWTH FACTOR COMPLEX
Biological source Homo sapiens
(human)
Cellular location
[UNP - P02766 ]
Secreted
Organ source
[UNP - P02766 ]
Liver
[UNP - P02766 ]
Platelet
[UNP - P02766 ]
Brain, Cajal-Retzius cell, and Fetal brain cortex
[UNP - P02766 ]
Plasma
[UNP - P02766 ]
Cerebrospinal fluid
Total number of polymer chains 2
Total molecular weight 28171 (the details in Structural Details Page )
Authors Palaninathan, S.K. , Smith, C. , Safe, S.H. , Kelly, J.W. , Sacchettini, J.C.
(deposition date : 2006-03-08, release date : 2006-03-21)
Primary citation Purkey, H.E. , Palaninathan, S.K. , Kent, K.C. , Smith, C. , Safe, S.H. , Sacchettini, J.C. , Kelly, J.W. Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity
Chem.Biol. ,
11:1719 - 1728, 2004.(PubMed : 15610856) (DOI: 10.1016/j.chembiol.2004.10.009)
Experimental method X-RAY DIFFRACTION ( 1.85[Å] )
Other Database Information