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MineSummary [1p10]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
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PDB ID1p10  sequence information (FASTA format)   
DescriptorALPHA-LYTIC PROTEASE (E.C.3.4.21.12) (MUTANT WITH MET 213 REPLACED BY ALA) (M213A) COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-VALINE BORONIC ACID
TitleSTRUCTURAL PLASTICITY AS A DETERMINANT OF ENZYME SPECIFICITY. CREATING BROADLY SPECIFIC PROTEASES
Functional KeywordsHYDROLASE (SERINE PROTEINASE)
Biological sourceLysobacter enzymogenes
Total number of polymer chains2
Total molecular weight20267.4 (the details in Structural Details Page)
AuthorsBone, R. , Agard, D.A. (deposition date : 1989-04-24, release date : 1990-04-15)
Primary citationBone, R. , Silen, J.L. , Agard, D.A.
Structural plasticity broadens the specificity of an engineered protease.
Nature, 339:191 - 195, 1989.(PubMed : 2716847)  (DOI: 10.1038/339191a0)
Experimental methodX-RAY DIFFRACTION ( 2.25[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P00778 ) , eF-site , KEGG ( EC 3.4.21.12 ) , PISA