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MineSummary [1qsh]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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PDB ID1qsh  sequence information (FASTA format)   
RELATED PDB ID1qsi
DescriptorHEMOGLOBIN ALPHA CHAIN/HEMOGLOBIN BETA CHAIN
TitleMAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME
Functional KeywordsHEMOGLOBIN; OXYGEN AFFINITY; ALLOSTERIC EFFECT; METAL SUBSTITUTION; TRIGGER MECHANISM, OXYGEN STORAGE/TRANSPORT COMPLEX
Biological sourceHomo sapiens (human)
Organ source [UNP - P69905] Blood
[UNP - P69905] Bone marrow, Brain, Lung, and Spleen
[UNP - P69905] Platelet
[UNP - P68871] Lymphocyte
[UNP - P68871] Spleen
[UNP - P68871] Skeletal muscle
[UNP - P68871] Epithelium
Total number of polymer chains4
Total molecular weight64484.8 (the details in Structural Details Page)
AuthorsMiyazaki, G. , Morimoto, H. , Yun, K.-M. , Park, S.-Y. , Nakagawa, A. , Minagawa, H. , Shibayama, N. (deposition date : 1999-06-22, release date : 1999-07-02)
Primary citationMiyazaki, G. , Morimoto, H. , Yun, K.M. , Park, S.Y. , Nakagawa, A. , Minagawa, H. , Shibayama, N.
Magnesium(II) and zinc(II)-protoporphyrin IX's stabilize the lowest oxygen affinity state of human hemoglobin even more strongly than deoxyheme.
J. Mol. Biol., 292:1121 - 1136, 1999.(PubMed : 10512707)  (DOI: 10.1006/jmbi.1999.3124)
Experimental methodX-RAY DIFFRACTION ( 1.70[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P69905, P68871 ) , eF-site , PISA