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MineSummary [1ra5]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>

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PDB ID1ra5  sequence information (FASTA format)   
RELATED PDB ID1k7o, 1r9x, 1r9y, 1r9z, 1ra0, 1rak, 1rb7
DescriptorCytosine deaminase (E.C.3.5.4.1)
TitleBacterial cytosine deaminase D314A mutant bound to 5-fluoro-4-(S)-hydroxyl-3,4-dihydropyrimidine.
Functional KeywordsCYTOSINE DEAMINASE, ALPHA-BETA BARREL, HEXAMER, CONFORMATIONAL CHANGE, D314A mutant, HYDROLASE
Biological sourceEscherichia coli
Total number of polymer chains1
Total molecular weight48096.5 (the details in Structural Details Page)
AuthorsMahan, S.D. , Ireton, G.C. , Stoddard, B.L. , Black, M.E. (deposition date : 2003-10-31, release date : 2004-10-05)
Primary citationMahan, S.D. , Ireton, G.C. , Knoeber, C. , Stoddard, B.L. , Black, M.E.
Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17:625 - 633, 2004.(PubMed : 15381761)  (DOI: 10.1093/protein/gzh074)
Experimental methodX-RAY DIFFRACTION ( 1.40[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P25524 ) , eF-site , KEGG ( EC 3.5.4.1 ) , PISA