PDB ID 1bwb sequence information (FASTA format)
Descriptor PROTEIN (HIV-1 PROTEASE) MUTANT (V82F, I84V)
Title HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH SD146 OF DUPONT PHARMACEUTICALS
Functional Keywords HIV-1 PROTEASE, HYDROLASE
Biological source Human immunodeficiency virus 1
Cellular location
[UNP - P04585 ]
Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential)
Total number of polymer chains 2
Total molecular weight 22472.5 (the details in Structural Details Page )
Authors Ala, P. , Chang, C.H.
(deposition date : 1998-09-22, release date : 1998-09-30)
Primary citation Ala, P.J. , Huston, E.E. , Klabe, R.M. , Jadhav, P.K. , Lam, P.Y.S. , Chang, C.H. Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities.
Biochemistry ,
37:15042 - 15049, 1998.(PubMed : 9790666) (DOI: 10.1021/bi980386e)
Experimental method X-RAY DIFFRACTION ( 1.8[Å] )
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