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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID1bwb  sequence information (FASTA format)   
DescriptorPROTEIN (HIV-1 PROTEASE) MUTANT (V82F, I84V)
TitleHIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH SD146 OF DUPONT PHARMACEUTICALS
Functional KeywordsHIV-1 PROTEASE, HYDROLASE
Biological sourceHuman immunodeficiency virus 1
Cellular location [UNP - P04585] Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential)
Total number of polymer chains2
Total molecular weight22472.5 (the details in Structural Details Page)
AuthorsAla, P. , Chang, C.H. (deposition date : 1998-09-22, release date : 1998-09-30)
Primary citationAla, P.J. , Huston, E.E. , Klabe, R.M. , Jadhav, P.K. , Lam, P.Y.S. , Chang, C.H.
Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities.
Biochemistry, 37:15042 - 15049, 1998.(PubMed : 9790666)  (DOI: 10.1021/bi980386e)
Experimental methodX-RAY DIFFRACTION ( 1.8[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P04585 ) , eF-site , KEGG ( EC 3.4.23.16 ) , PISA