PDB ID 1t7j sequence information (FASTA format)
RELATED PDB ID 1f7a , 1t3r
Descriptor Pol Polyprotein (E.C.3.4.23.16)
Title crystal structure of inhibitor amprenavir in complex with a multi-drug resistant variant of HIV-1 protease (L63P/V82T/I84V)
Functional Keywords HIV-1 PROTEASE, DRUG RESITANCE, THERMODYNAMICS, SUBSTRATE ENVELOPE, HYDROLASE
Biological source Human immunodeficiency virus 1
Cellular location
[UNP - P35963 ]
Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential)
Total number of polymer chains 2
Total molecular weight 22405.2 (the details in Structural Details Page )
Authors King, N.M. , Prabu-Jeyabalan, M. , Nalivaika, E.A. , Wigerinck, P.B.T.P. , De Bethune, M.-P. , Schiffer, C.A.
(deposition date : 2004-05-10, release date : 2005-05-10)
Primary citation Surleraux, D.L.N.G. , Tahri, A. , Verschueren, W.G. , Pille, G.M.E. , de Kock, H.A. , Jonckers, T.H.M. , Peeters, A. , De Meyer, S. , Azijn, H. , Pauwels, R. , de Bethune, M.-P. , King, N.M. , Prabu-Jeyabalan, M. , Schiffer, C.A. , Wigerinck, P.B.T.P.J.Med.Chem. ,
48:1813 - 1822, 2005.(PubMed : 15771427) (DOI: 10.1021/jm049560p)
Experimental method X-RAY DIFFRACTION ( 2.20[Å] )
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