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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID1qwh  sequence information (FASTA format)   
DescriptorTransthyretin
Titlea covalent dimer of transthyretin that affects the amyloid pathway
Functional Keywordsthyroid hormone, liver, plasma, cerebrospinal fluid, polyneuropathy, signal, polymorphism, disease mutation, transport, thyroxine, binding protein, HORMONE/GROWTH FACTOR COMPLEX
Biological sourceHomo sapiens (human)
Cellular location [UNP - P02766] Secreted
Organ source [UNP - P02766] Liver
[UNP - P02766] Platelet
[UNP - P02766] Brain, Cajal-Retzius cell, and Fetal brain cortex
[UNP - P02766] Plasma
[UNP - P02766] Cerebrospinal fluid
Total number of polymer chains2
Total molecular weight25717 (the details in Structural Details Page)
AuthorsFoss, T. , Kelker, M.S. , Wilson, I.A. (deposition date : 2003-09-02, release date : 2004-09-14)
Primary citationFoss, T.R. , Kelker, M.S. , Wiseman, R.L. , Wilson, I.A. , Kelly, J.W.
Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis.
J. Mol. Biol., 347:841 - 854, 2005.(PubMed : 15769474)  (DOI: 10.1016/j.jmb.2005.01.050)
Experimental methodX-RAY DIFFRACTION ( 1.36[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P02766 ) , eF-site , PISA