PDB ID 2rf2 sequence information (FASTA format)
Descriptor Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p66 RT) (E.C.2.7.7.49)
Title HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)
Functional Keywords HIV-1 revers transcriptase, AIS, non-nucleoside inhibition, nucleotidyltransferase, AIDS, Aspartyl protease, Capsid maturation, Core protein, Cytoplasm, DNA integration, DNA recombination, DNA-directed DNA polymerase, Endonuclease, Host-virus interaction, Hydrolase, Lipoprotein, Magnesium, Membrane, Metal-binding, Multifunctional enzyme, Myristate, Nuclease, Nucleus, Phosphorylation, Protease, RNA-binding, RNA-directed DNA polymerase, Viral nucleoprotein, Virion, Zinc, Zinc-finger
Biological source HIV-1 M:B_HXB2R
Cellular location
[UNP - P04585 ]
Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential)
Total number of polymer chains 2
Total molecular weight 117000.3 (the details in Structural Details Page )
Authors Yan, Y. , Prasad, S.
(deposition date : 2007-09-27, release date : 2008-01-01)
Primary citation Zhao, Z. , Wolkenberg, S.E. , Lu, M. , Munshi, V. , Moyer, G. , Feng, M. , Carella, A.V. , Ecto, L.T. , Gabryelski, L.J. , Lai, M.T. , Prasad, S.G. , Yan, Y. , McGaughey, G.B. , Miller, M.D. , Lindsley, C.W. , Hartman, G.D. , Vacca, J.P. , Williams, T.M.Bioorg.Med.Chem.Lett. ,
18:554 - 559, 2008.(PubMed : 18083561) (DOI: 10.1016/j.bmcl.2007.11.085)
Experimental method X-RAY DIFFRACTION ( 2.4[Å] )
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