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MineSummary [2eb3]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>

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PDB ID2eb3  sequence information (FASTA format)   
RELATED PDB ID2eb2, 2zge, 2zgf
DescriptorEpidermal growth factor receptor (E.C.2.7.10.1)
TitleCrystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP
Functional KeywordsKinase, Tyrosine-protein kinase, Receptor, Transferase, Phosphorylation, ATP-binding, Disease mutation, Transmembrane, Cell cycle, EC 2.7.10.1, Structural Genomics, NPPSFA, National Project on Protein Structural and Functional Analyses, RIKEN Structural Genomics/Proteomics Initiative, RSGI
TRANSFERASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P00533] Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted
Organ source [UNP - P00533] Placenta
[UNP - P00533] Epithelium
[UNP - P00533] Hepatocyte
Total number of polymer chains1
Total molecular weight38528.5 (the details in Structural Details Page)
AuthorsYoshikawa, S. , Kukimoto-Niino, M. , Shirouzu, M. , Senba, K. , Yamamoto, T. , Yokoyama, S. , RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date : 2007-02-06, release date : 2008-02-12)
Primary citationYoshikawa, S. , Kukimoto-Niino, M. , Shirouzu, M. , Senba, K. , Yamamoto, T. , Yokoyama, S.
Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP
To be Published, : - , .
Experimental methodX-RAY DIFFRACTION ( 2.84[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P00533 ) , eF-site , KEGG ( EC 2.7.10.1 ) , PISA