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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
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PDB ID1kzi  sequence information (FASTA format)   
RELATED PDB ID1kzj
DescriptorThymidylate synthase (E.C.2.1.1.45)
TitleCrystal Structure of EcTS/dUMP/THF Complex
Functional KeywordsEnzyme substrate complex, TRANSFERASE
Biological sourceEscherichia coli
Cellular location [UNP - P0A884] Cytoplasm
Total number of polymer chains2
Total molecular weight63207.5 (the details in Structural Details Page)
AuthorsFritz, T.A. , Liu, L. , Finer-Moore, J.S. , Stroud, R.M. (deposition date : 2002-02-06, release date : 2002-07-03)
Primary citationFritz, T.A. , Liu, L. , Finer-Moore, J.S. , Stroud, R.M.
Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.
Biochemistry, 41:7021 - 7029, 2002.(PubMed : 12033935)  (DOI: 10.1021/bi012108c)
Experimental methodX-RAY DIFFRACTION ( 1.75[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P0A884 ) , eF-site , KEGG ( EC 2.1.1.45 ) , PISA