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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID2eu0  sequence information (FASTA format)   
RELATED PDB ID1lui, 1luk, 1lum, 1lun, 2etz
DescriptorTyrosine-protein kinase ITK/TSK (E.C.2.7.1.112)
TitleThe NMR ensemble structure of the Itk SH2 domain bound to a phosphopeptide
Functional Keywordscis/trans isomerization, interleukin-2 tyrosine kinase, Itk, t-cell specific kinase, tsk, src homology 2, SH2, proline, phosphotyrosine binding, TRANSFERASE
Biological sourceMus musculus (house mouse)
Cellular location [UNP - Q03526] Cell membrane
[UNP - Q60787] Cytoplasm (Probable)
Organ source [UNP - Q03526] Thymocyte
[UNP - Q03526] Mast cell
[UNP - Q60787] T-cell lymphoma
Total number of polymer chains2
Total molecular weight13355.1 (the details in Structural Details Page)
AuthorsSundd, M. , Pletneva, E.V. , Fulton, D.B. , Andreotti, A.H. (deposition date : 2005-10-27, release date : 2006-02-07)
Primary citationPletneva, E.V. , Sundd, M. , Fulton, D.B. , Andreotti, A.H.
Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide.
J.Mol.Biol., 357:550 - 561, 2006.(PubMed : 16436281)  (DOI: 10.1016/j.jmb.2005.12.073)
Experimental methodSOLUTION NMR
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( Q03526, Q60787 ) , eF-site , KEGG ( EC 2.7.1.112 ) , PISA , NRG-CING