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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID1lpk  sequence information (FASTA format)   
RELATED PDB ID1lpg, 1lpz, 1lqd, 1lqe
DescriptorCoagulation factor X (E.C.3.4.21.6)
TitleCRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 125.
Functional KeywordsProtein inhibitor complex, blood coagulation factor, serine proteinase, HYDROLASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P00742] Secreted
Organ source [UNP - P00742] Ovary
[UNP - P00742] Liver
Total number of polymer chains2
Total molecular weight44235.4 (the details in Structural Details Page)
AuthorsSchreuder, H.A. , Loenze, P. , Brachvogel, V. , Liesum, A. (deposition date : 2002-05-08, release date : 2003-05-08)
Primary citationMatter, H. , Defossa, E. , Heinelt, U. , Blohm, P.M. , Schneider, D. , Mueller, A. , Herok, S. , Schreuder, H. , Liesum, A. , Brachvogel, V. , Loenze, P. , Walser, A. , Al-Obeidi, F. , Wildgoose, P.
Design and quantitative structure-activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa
J. Med. Chem., 45:2749 - 2769, 2002.(PubMed : 12061878)  (DOI: 10.1021/jm0111346)
Experimental methodX-RAY DIFFRACTION ( 2.20[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P00742 ) , eF-site , KEGG ( EC 3.4.21.6 ) , PISA