English Statistics Help FAQ Contact Us
Download >>

PDBj (Protein Data Bank Japan) maintains a centralized PDB archive of macromolecular structures and provides integrated tools, in collaboration with the RCSB, the BMRB in USA and the PDBe in EU. PDBj is supported by JST-NBDC and Osaka University.

Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

More images...
View in 3D molecule viewer
( jV3 / Jmol ) *1
PDB ID2fwz  sequence information (FASTA format)   
RELATED PDB ID1zw9, 1uy6, 2fwy
DescriptorHeat shock protein HSP 90-alpha
TitleStructure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H71
Functional KeywordsHSP90, GRP94, chaperone, purine, PU3, H64, H71
CHAPERONE
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight29285.8 (the details in Structural Details Page)
AuthorsImmormino, R.M. , Gewirth, D.T. (deposition date : 2006-02-03, release date : 2006-10-03)
Primary citationImmormino, R.M. , Kang, Y. , Chiosis, G. , Gewirth, D.T.
Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors.
J.Med.Chem., 49:4953 - 4960, 2006.(PubMed : 16884307)  (DOI: 10.1021/jm060297x)
Experimental methodX-RAY DIFFRACTION ( 2.10[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , GenBank/DDBJ/EMBL (GB - 61656605) , eF-site , PISA