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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID2ohq  sequence information (FASTA format)   
RELATED PDB ID2of0, 2ohk, 2ohl, 2ohm, 2ohn, 2ohp, 2ohr, 2ohs, 2oht, 2ohu
DescriptorBeta-secretase 1 (E.C.3.4.23.46)
TitleX-ray crystal structure of beta secretase complexed with compound 4
Functional KeywordsALTERNATIVE SPLICING, ALZHEIMER'S DISEASE, ASPARTIC PROTEASE, ASPARTYL PROTEASE, BASE, BETA-SECRETASE, GLYCOPROTEIN, HYDROLASE, MEMAPSIN 2, SIGNAL, TRANSMEMBRANE, ZYMOGEN
Biological sourceHomo sapiens (human)
Cellular location [UNP - P56817] Membrane; Single-pass type I membrane protein
Organ source [UNP - P56817] Brain
[UNP - P56817] Brain, and Pancreas
[UNP - P56817] Pancreas
[UNP - P56817] Lung
Total number of polymer chains1
Total molecular weight45570.3 (the details in Structural Details Page)
AuthorsPatel, S. (deposition date : 2007-01-10, release date : 2007-03-13)
Primary citationCongreve, M. , Aharony, D. , Albert, J. , Callaghan, O. , Campbell, J. , Carr, R.A. , Chessari, G. , Cowan, S. , Edwards, P.D. , Frederickson, M. , McMenamin, R. , Murray, C.W. , Patel, S. , Wallis, N.
Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.
J.Med.Chem., 50:1124 - 1132, 2007.(PubMed : 17315857)  (DOI: 10.1021/jm061197u)
Experimental methodX-RAY DIFFRACTION ( 2.100[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P56817 ) , eF-site , KEGG ( EC 3.4.23.46 ) , PISA