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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID2pzr  sequence information (FASTA format)   
RELATED PDB ID2psq, 2pvf, 2pvy, 2pwl, 2py3, 2pz5, 2pzp, 2q0b
DescriptorFibroblast growth factor receptor 2 (E.C.2.7.10.1)
TitleCrystal Strucure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K641R Mutation Responsible for Pfeiffer Syndrome
Functional KeywordsKinase Domain Fold Consisting of N- and C-lobes, transferase
Biological sourceHomo sapiens (human)
Cellular location [UNP - P21802] Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted
Organ source [UNP - P21802] Neonatal brain stem
[UNP - P21802] Stomach cancer
[UNP - P21802] Placenta
[UNP - P21802] Mammary gland
[UNP - P21802] Cornea, and Mammary gland
[UNP - P21802] Blood
[UNP - P21802] Brain
Total number of polymer chains2
Total molecular weight75672.6 (the details in Structural Details Page)
AuthorsChen, H. , Mohammadi, M. (deposition date : 2007-05-18, release date : 2007-09-25)
Primary citationChen, H. , Ma, J. , Li, W. , Eliseenkova, A.V. , Xu, C. , Neubert, T.A. , Miller, W.T. , Mohammadi, M.
A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27:717 - 730, 2007.(PubMed : 17803937)  (DOI: 10.1016/j.molcel.2007.06.028)
Experimental methodX-RAY DIFFRACTION ( 3.0[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P21802 ) , eF-site , KEGG ( EC 2.7.10.1 ) , PISA