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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>

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( jV3 / Jmol ) *1
PDB ID3cn2  sequence information (FASTA format)   
RELATED PDB ID2qgb, 3cn0, 3cn1, 3cn3, 3cn4
DescriptorTransthyretin
TitleHuman transthyretin (TTR) in complex with 3,5-Dibromo-4-hydroxybiphenyl
Functional KeywordsTransthyretin, Tetramer, Hormone, Transport protein
Biological sourceHomo sapiens (human)
Cellular location [UNP - P02766] Secreted
Organ source [UNP - P02766] Liver
[UNP - P02766] Platelet
[UNP - P02766] Brain, Cajal-Retzius cell, and Fetal brain cortex
[UNP - P02766] Plasma
[UNP - P02766] Cerebrospinal fluid
Total number of polymer chains2
Total molecular weight28211 (the details in Structural Details Page)
AuthorsConnelly, S. , Wilson, I.A. (deposition date : 2008-03-24, release date : 2008-10-28)
Primary citationJohnson, S.M. , Connelly, S. , Wilson, I.A. , Kelly, J.W.
Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
J.Med.Chem., 51:6348 - 6358, 2008.(PubMed : 18811132)  (DOI: 10.1021/jm800435s)
Experimental methodX-RAY DIFFRACTION ( 1.520[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P02766 ) , eF-site , PISA