English Statistics Help FAQ Contact Us
Download >>

PDBj (Protein Data Bank Japan) maintains a centralized PDB archive of macromolecular structures and provides integrated tools, in collaboration with the RCSB, the BMRB in USA and the PDBe in EU. PDBj is supported by JST-NBDC and Osaka University.

Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

More images...
View in 3D molecule viewer
( jV3 / Jmol ) *1
PDB ID3ddw  sequence information (FASTA format)   
RELATED PDB ID3dd1, 3dds
DescriptorGlycogen phosphorylase, liver form (E.C.2.4.1.1)
TitleCrystal structure of glycogen phosphorylase complexed with an anthranilimide based inhibitor GSK055
Functional KeywordsGlycogen Phosphorylase, GP, Diabetes, Acetylation, Allosteric enzyme, Carbohydrate metabolism, Disease mutation, Glycogen metabolism, Glycogen storage disease, Glycosyltransferase, Nucleotide-binding, Phosphoprotein, Polymorphism, Pyridoxal phosphate, Transferase
TRANSFERASE
Biological sourceHomo sapiens
Organ source [UNP - P06737] Liver
[UNP - P06737] Blood
[UNP - P06737] Placenta, Skin, and Uterus
[UNP - P06737] Fetal brain
[UNP - P06737] Epithelium
Total number of polymer chains2
Total molecular weight197607.8 (the details in Structural Details Page)
AuthorsNolte, R.T. (deposition date : 2008-06-06, release date : 2009-01-27)
Primary citationThomson, S.A. , Banker, P. , Bickett, D.M. , Boucheron, J.A. , Carter, H.L. , Clancy, D.C. , Cooper, J.P. , Dickerson, S.H. , Garrido, D.M. , Nolte, R.T. , Peat, A.J. , Sheckler, L.R. , Sparks, S.M. , Tavares, F.X. , Wang, L. , Wang, T.Y. , Weiel, J.E.
Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy.
Bioorg.Med.Chem.Lett., 19:1177 - 1182, 2009.(PubMed : 19138846)  (DOI: 10.1016/j.bmcl.2008.12.085)
Experimental methodX-RAY DIFFRACTION ( 1.90[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P06737 ) , eF-site , KEGG ( EC 2.4.1.1 ) , PISA