PDB ID 3ddw sequence information (FASTA format)
RELATED PDB ID 3dd1 , 3dds
Descriptor Glycogen phosphorylase, liver form (E.C.2.4.1.1)
Title Crystal structure of glycogen phosphorylase complexed with an anthranilimide based inhibitor GSK055
Functional Keywords Glycogen Phosphorylase, GP, Diabetes, Acetylation, Allosteric enzyme, Carbohydrate metabolism, Disease mutation, Glycogen metabolism, Glycogen storage disease, Glycosyltransferase, Nucleotide-binding, Phosphoprotein, Polymorphism, Pyridoxal phosphate, Transferase TRANSFERASE
Biological source Homo sapiens
Organ source
[UNP - P06737 ]
Liver
[UNP - P06737 ]
Blood
[UNP - P06737 ]
Placenta, Skin, and Uterus
[UNP - P06737 ]
Fetal brain
[UNP - P06737 ]
Epithelium
Total number of polymer chains 2
Total molecular weight 197607.8 (the details in Structural Details Page )
Authors Nolte, R.T.
(deposition date : 2008-06-06, release date : 2009-01-27)
Primary citation Thomson, S.A. , Banker, P. , Bickett, D.M. , Boucheron, J.A. , Carter, H.L. , Clancy, D.C. , Cooper, J.P. , Dickerson, S.H. , Garrido, D.M. , Nolte, R.T. , Peat, A.J. , Sheckler, L.R. , Sparks, S.M. , Tavares, F.X. , Wang, L. , Wang, T.Y. , Weiel, J.E. Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy.
Bioorg.Med.Chem.Lett. ,
19:1177 - 1182, 2009.(PubMed : 19138846) (DOI: 10.1016/j.bmcl.2008.12.085)
Experimental method X-RAY DIFFRACTION ( 1.90[Å] )
Other Database Information