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<Asymmetric unit>

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PDB ID1dx5  sequence information (FASTA format)   
DescriptorTHROMBIN LIGHT CHAIN (E.C.3.4.21.5), THROMBIN INHIBITOR L-GLU-L-GLY-L-ARM, THROMBOMODULIN, THROMBIN HEAVY CHAIN (E.C.3.4.21.5)
TitleCRYSTAL STRUCTURE OF THE THROMBIN-THROMBOMODULIN COMPLEX
Functional KeywordsSERINE PROTEINASE, EGF-LIKE DOMAINS, ANTICOAGULANT COMPLEX, ANTIFIBRINOLYTIC COMPLEX
Biological sourceHOMO SAPIENS (HUMAN)
Cellular location [UNP - P00734] Secreted, extracellular space
[UNP - P07204] Membrane; Single-pass type I membrane protein
Organ source [UNP - P00734] Mammary gland
[UNP - P00734] Plasma
[UNP - P07204] Brain, and Lung
Total number of polymer chains16
Total molecular weight189213.6 (the details in Structural Details Page)
AuthorsFuentes-Prior, P. , Iwanaga, Y. , Huber, R. , Pagila, R. , Rumennik, G. , Seto, M. , Morser, J. , Light, D.R. , Bode, W. (deposition date : 1999-12-20, release date : 2000-04-10)
Primary citationFuentes-Prior, P. , Iwanaga, Y. , Huber, R. , Pagila, R. , Rumennik, G. , Seto, M. , Morser, J. , Light, D.R. , Bode, W.
Structural Basis for the Anticoagulant Activity of the Thrombin-Thrombomodulin Complex
Nature, 404:518 - , 2000.(PubMed : 10761923)  (DOI: 10.1038/35006683)
Experimental methodX-RAY DIFFRACTION ( 2.30[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P00734, P07204 ) , eF-site , KEGG ( EC 3.4.21.5 ) , PISA