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MineSummary [2zdz]

Summary Structural Experimental Function Sequence Neighbor Download Link

<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID2zdz  sequence information (FASTA format)   
RELATED PDB ID2qu2, 2qu3
DescriptorBeta-secretase 1 (E.C.3.4.23.46)
TitleX-ray structure of Bace-1 in complex with compound 3.b.10
Functional KeywordsBACE, Aspartyl Protease, Acylguanidine Inhibitor, Alternative splicing, Glycoprotein, Hydrolase, Membrane, Transmembrane, Zymogen
HYDROLASE
Biological sourceHomo sapiens (Human)
Cellular location [UNP - P56817] Membrane; Single-pass type I membrane protein
Organ source [UNP - P56817] Brain
[UNP - P56817] Brain, and Pancreas
[UNP - P56817] Pancreas
[UNP - P56817] Lung
Total number of polymer chains1
Total molecular weight46928.5 (the details in Structural Details Page)
AuthorsChopra, R. , Olland, A. (deposition date : 2007-12-04, release date : 2008-12-09)
Primary citationCole, D.C. , Stock, J.R. , Chopra, R. , Cowling, R. , Ellingboe, J.W. , Fan, K.Y. , Harrison, B.L. , Hu, Y. , Jacobsen, S. , Jennings, L.D. , Jin, G. , Lohse, P.A. , Malamas, M.S. , Manas, E.S. , Moore, W.J. , O'Donnell, M.M. , Olland, A.M. , Robichaud, A.J. , Svenson, K. , Wu, J. , Wagner, E. , Bard, J.
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
Bioorg.Med.Chem.Lett., 18:1063 - 1066, 2008.(PubMed : 18162398)  (DOI: 10.1016/j.bmcl.2007.12.010)
Experimental methodX-RAY DIFFRACTION ( 2.00[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P56817 ) , eF-site , KEGG ( EC 3.4.23.46 ) , PISA