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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID1m27  sequence information (FASTA format)   
RELATED PDB ID1d4t
DescriptorSH2 domain protein 1A, Proto-oncogene tyrosine-protein kinase FYN (E.C.2.7.1.112), Signaling lymphocytic activation molecule
TitleCrystal structure of SAP/FynSH3/SLAM ternary complex
Functional KeywordsSH2-SH3 interaction, SIGNALING PROTEIN, TRANSFERASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - O60880] Cytoplasm (Probable)
[UNP - P06241] Cell membrane
[UNP - Q13291] Cell membrane; Single-pass type I membrane protein
Organ source [UNP - O60880] Lung
[UNP - P06241] Placenta
[UNP - P06241] T-cell
[UNP - P06241] Blood
[UNP - P06241] Platelet
Total number of polymer chains3
Total molecular weight20110.7 (the details in Structural Details Page)
AuthorsChan, B. , Griesbach, J. , Song, H.K. , Poy, F. , Terhorst, C. , Eck, M.J. (deposition date : 2002-06-21, release date : 2003-05-06)
Primary citationChan, B. , Lanyi, A. , Song, H.K. , Griesbach, J. , Simarro-Grande, M. , Poy, F. , Howie, D. , Sumegi, J. , Terhorst, C. , Eck, M.J.
SAP couples Fyn to SLAM immune receptors.
Nat. Cell. Biol., 5:155 - 160, 2003.(PubMed : 12545174)  (DOI: 10.1038/ncb920)
Experimental methodX-RAY DIFFRACTION ( 2.5[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( O60880, P06241, Q13291 ) , eF-site , PISA