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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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PDB ID1f2c  sequence information (FASTA format)   
RELATED PDB ID1f29, 1f2a, 1f2b, 1aim, 2aim, 1ewl, 1ewm, 1ewo, 1ewp
DescriptorCRUZAIN (E.C.3.4.22.-)
TitleCRYSTAL STRUCTURE ANALYSIS OF CRYZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (IV)
Functional Keywordscysteine protease, covalent inhibitor, vinyl sulfonamide derived, P1' pocket, HYDROLASE
Biological sourceTrypanosoma cruzi
Total number of polymer chains1
Total molecular weight23337.1 (the details in Structural Details Page)
AuthorsBrinen, L.S. , Hansell, E. , Roush, W.R. , McKerrow, J.H. , Fletterick, R.J. (deposition date : 2000-05-23, release date : 2000-07-26)
Primary citationBrinen, L.S. , Hansell, E. , Cheng, J. , Roush, W.R. , McKerrow, J.H. , Fletterick, R.J.
A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Structure Fold.Des., 8:831 - 840, 2000.(PubMed : 10997902)  (DOI: 10.1016/S0969-2126(00)00173-8)
Experimental methodX-RAY DIFFRACTION ( 2.0[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P25779 ) , eF-site , KEGG (EC 3.4.22.- ) , PISA