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Summary Structural Experimental Function Sequence Neighbor Download Link


<Asymmetric unit>
= <Biological unit>

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( jV3 / Jmol ) *1
PDB ID1g48  sequence information (FASTA format)   
RELATED PDB ID1g1d, 1g3z, 1g45, 1g46
DescriptorCARBONIC ANHYDRASE II (E.C.4.2.1.1)
TitleCARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE
Functional KeywordsCarbonic Anhydrase II, F131V, 4-(aminosulfonyl)-N-[(2,6-difluorophenyl)methyl]-benzamide, LYASE
Biological sourceHomo sapiens (human)
Cellular location [UNP - P00918] Cytoplasm
Organ source [UNP - P00918] Ovary
Total number of polymer chains1
Total molecular weight29702.4 (the details in Structural Details Page)
AuthorsKim, C.-Y. , Chang, J.S. , Doyon, J.B. , Baird Jr., T.T. , Fierke, C.A. , Jain, A. , Christianson, D.W. (deposition date : 2000-10-26, release date : 2000-11-08)
Primary citationKim, C.-Y. , Chang, J.S. , Doyon, J.B. , Baird Jr., T.T. , Fierke, C.A. , Jain, A. , Christianson, D.W.
Contribution of Flourine to Protein-ligand Affinity in the Binding of Flouroaromatic Inhibitors to Carbonic Anhydrase II
J.Am.Chem.Soc., 122:12125 - 12134, 2000.  (DOI: 10.1021/ja002627n)
Experimental methodX-RAY DIFFRACTION ( 1.86[Å] )
Other Database Information
Yorodumi , CATH , CE , FSSP , SCOP , VAST , UniProt ( P00918 ) , eF-site , KEGG ( EC 4.2.1.1 ) , PISA