Gene information | Cerebellar Development Transcriptome Database (CDT-DB)

20114085 Lack of B7-1 and B7-2 costimulatory molecules modulates the severity of group B Streptococcus-induced arthritis
19933871 B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion
19917682 Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination for the maintenance of conventional dendritic cells
19843945 Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions
19757438 B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function

Show all (10) references (detailed information)

CD gene Number	CD17926
Gene Symbol	Cd86
Gene description	CD86 antigen
Alternative name(s)	T-lymphocyte activation antigen CD86; OTTMUSP00000015940; activation B7-2 antigen; early T cell costimulatory molecule-1; early T-cell costimulatory molecule 1
Alternative name(s)	B7, B70, MB7, B7-2, B7.2, CLS1, Ly58, ETC-1, Ly-58, MB7-2, Cd28l2, TS/A-2
Accession ID	NM_019388
Gene Category
Gene Ontology	biological_process B cell activation , T cell activation , T cell proliferation , toll-like receptor signaling pathway cellular_component external side of plasma membrane , integral to membrane , intracellular membrane-bounded organelle , membrane molecular_function receptor activity
Temporal expression	up-and-down regulation
Spatial expression (characteristic site)	P7 : P21 :
Brain distribution (characteristic site)	P7 : P21 :
Brain specificity
Experimental data	Temporal Tissue
Probe	CDT EST : Affymetrix : 1420404_at (MG 430 2.0 Array)
Links	General information Entrez Gene : 12524 MGI : 101773 Ensembl : ENSMUSG00000022901 UniGene : Mm.1452 OMIM : 601020 GEO : Cd86 KEGG : Allograft rejection 05330, Autoimmune thyroid disease 05320, Cell adhesion molecules (CAMs) 04514, Graft-versus-host disease 05332, Intestinal immune network for IgA production 04672, Systemic lupus erythematosus 05322, Toll-like receptor signaling pathway 04620, Type I diabetes mellitus 04940, Viral myocarditis 05416 Genome information Harvester UCSC Mouse Genome Browser Gateway Perlegen/NIEHS Mouse Genome Browser Functional genomics GeneNetwork Mouse Phenome Database BioGPS STRING Nervous system SynDB Mouse Neuronal Expression Database Reference information GoPubMed iHOP PubMed Spatial information ABA GenePaint BGEM
References	20114085 Lack of B7-1 and B7-2 costimulatory molecules modulates the severity of group B Streptococcus-induced arthritis 19933871 B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion 19917682 Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination for the maintenance of conventional dendritic cells 19843945 Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions 19757438 B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function Show all (10) references (detailed information)