InterProInterPro Protein Domain record

Neutrophil cytosol factor 2 p67phox
http://metadb.riken.jp/db/SciNetS_rib124i/crib124s1rib124u108i

Neutrophil cytosol factor 2 p67phox

InterPro Protein Domain record

description
  • Phagocytes form the first line of defence against invasion by micro-organisms. Engulfing of bacteria by neutrophils is accompanied by theconsumption of large amounts of oxygen - a so-called respiratory burst.Defects in phagocytosis involving the lack of a respiratory burst giverise to chronic granulomatous disease (CGD), in which patients are pre-disposed to infection, often from otherwise non-pathogenic bacteria [<cite idref="PUB00003781"/>].<p>Regulation of the respiratory burst takes place at the phagocytic vacuole.The process is mediated by NADPH oxidase, which transports electrons acrossthe plasma membrane to form superoxide (an oxygen molecule with an extraelectron that is toxic to normal cells) in the vacuole interior. Theelectrons are carried across the membrane by a short electron transportchain in the form of an unusual flavocytochrome b [<cite idref="PUB00003781"/>].To conserve NADPH and avoid the toxic effects of superoxide, the oxidase remains inactive until it receives an appropriate stimulus. Activationinvolves the participation of a number of cytosolic proteins, some of which attach to the flavocytochrome.</p> <p> P47phox, p67phox and p40phox arespecialised components of phagocytic cells, all of which contain SH3domains <db_xref db="INTERPRO" dbkey="IPR001452"/>, by means of which they attach to proline-rich regions of otherproteins. Upon activation, p47phox and p67phox are phosphorylated and,with p40phox, translocate to the region of the plasma membrane formingthe phagocytic vacuole, where they associates with hydrophilic regionsof the flavocytochrome [<cite idref="PUB00003781"/>].</p>
label
  • Neutrophil cytosol factor 2 p67phox
attributionURL
signatures_SMART
type
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PDB_structure
Os_RAPDB_Locus