InterProInterPro Protein Domain record

DNA-repair protein, UmuC-like
http://metadb.riken.jp/db/SciNetS_rib124i/crib124s1rib124u1126i

DNA-repair protein, UmuC-like

InterPro Protein Domain record

description
  • <p>In <taxon tax_id="562">Escherichia coli</taxon>, UV and many chemicals appear to cause mutagenesis by a process of translesion synthesis that requires DNA polymerase III and the SOS-regulated proteins UmuD, UmuC and RecA. This machinery allows the replication to continue through DNA lesion, and therefore avoid lethal interruption of DNA replication after DNA damage [<cite idref="PUB00010596"/>]. UmuC is a well conserved protein in prokaryotes, with a homologue in yeast species.</p><p>Proteins currently known to belong to this family are listed below:<ul><li>E. coli MucB protein. Plasmid-born analogue of the UmuC protein.</li><li> <taxon tax_id="4932">Saccharomyces cerevisiae</taxon> (Baker's yeast) Rev1 protein. Homologue of UmuC also required for normal induction of mutations by physical and chemical agents. </li><li> <taxon tax_id="602">Salmonella typhimurium</taxon> ImpB protein. Plasmid-born analogue of the UmuC protein.</li><li>Bacterial UmuC protein.</li><li>E. coli DNA-damage-inducible protein P (DinP).</li><li>S. typhimurium SamB homologue of UmuC plasmid associated.</li></ul></p>
label
  • DNA-repair protein, UmuC-like
attributionURL
signatures_SMART
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PDB_structure
InterPro Protein Domain record
Os_RAPDB_Locus
Pfam-A