InterProInterPro Protein Domain record

Galactokinase/homoserine kinase
http://metadb.riken.jp/db/SciNetS_rib124i/crib124s1rib124u1174i

Galactokinase/homoserine kinase

InterPro Protein Domain record

description
  • <p>The lincomycin (LM)-production gene cluster of an over-producing strain of<taxon tax_id="1915">Streptomyces lincolnensis</taxon> has been analysed [<cite idref="PUB00003870"/>]. The lmb/lmr gene cluster contains 27 open reading frames with putative biosynthetic orregulatory functions (lmb genes) and three resistance (lmr) genes [<cite idref="PUB00003870"/>]. </p><p>Only a minority of the putative Lmb proteins belong to known proteinfamilies: these include members of the gamma-glutamyl transferases (LmbA);amino acid acylases (LmbC); aromatic amino acid aminotransferases (LmbF);imidazoleglycerolphosphate dehydratases (LmbK); dTDP-glucose synthases(LmbO); dTDP-glucose 4,6-dehydratases (LmbM); and (NDP-) ketohexose (or ketocyclitol) aminotransferases (LmbS) [<cite idref="PUB00003870"/>]. </p><p>LmbP seems to show some similarity to a family of enzymes that share anN-terminal Gly/Ser-rich putative ATP-binding region: these include galacto-kinase (<db_xref db="EC" dbkey="2.7.1.6"/>), homoserine kinase (<db_xref db="EC" dbkey="2.7.1.39"/>), mevalonate kinase (<db_xref db="EC" dbkey="2.7.1.36"/>) and phosphomevalonate kinase[<cite idref="PUB00003676"/>]. Sequence v031 from <taxon tax_id="1773">Mycobacterium tuberculosis</taxon> [<cite idref="PUB00004888"/>] is also a homologue.</p>
label
  • Galactokinase/homoserine kinase
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Os_RAPDB_Locus