<p>Copper type II, ascorbate-dependent monooxygenases [<cite idref="PUB00001578"/>] are a class of enzymes that requires copper as a cofactor and which uses ascorbate as an electron donor. This family contains two related enzymes, Dopamine-beta-monooxygenase (<db_xref db="EC" dbkey="1.14.17.1"/>)and Peptidyl-glycine alpha-amidating monooxygenase (<db_xref db="EC" dbkey="1.14.17.3"/>).There are a few regions of sequence similarities between these two enzymes,two of these regions contain clusters of conserved histidine residues whichare most probably involved in binding copper.</p><p>This entry represents a conserved site that covers the second cluster of conserved histidine residues.</p>