<p>The sequences in this family contain the pyridoxal binding domain and C-terminal sheet domain of a family of Pyridoxal-dependent decarboxylases. Characterised enzymes in this family decarboxylate substrates such as ornithine, diaminopimelate and arginine. The proteins found in tyhis entry, with the exception of those observed in certain Burkholderia species, are all found in the context of exopolysaccharide biosynthesis loci containing the exosortase/PEP-CTERM protein sorting system [<cite idref="PUB00034422"/>]. More specifically, these are characteristic of the type 1 exosortase system represented by <db_xref db="GENPROP" dbkey="GenProp0652"/>. The substrate of these enzymes may be a precursor of the carrier or linker which is hypothesized to release the PEP-CTERM protein from the exosortase enzyme. These enzymes are apparently most closely related to the diaminopimelate decarboxylase found in <db_xref db="INTERPRO" dbkey="IPR002986"/>, which may suggest a similarity (or identity) of substrate.</p>