<p>This entry contains metal dependent phosphohydrolases, which include 2',3'-cyclic-nucleotide 2'-phosphodiesterase (<db_xref db="EC" dbkey="3.1.4.16"/>) which catalyses the hydrolysis of both 2',3'-cyclic AMP and 2',3'-cyclic GMP into 3'-AMP and 3'-GMP, respectively, at the 3'-terminal of RNA [<cite idref="PUB00044724"/>].</p><p>Proteins in this entry belong to <db_xref db="EC" dbkey="3.1.4.16"/> and catalyse the reaction <reaction>Nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate</reaction> </p>